NTM Monthly

The latest research in NTM

NTM Monthly features information about recent publications and research involving nontuberculous mycobacterial (NTM) lung disease and related lung conditions. Sign up to receive these research highlights in your inbox every month

Issue
1

April 1, 2020

Non-tuberculous mycobacterial infections - A neglected and emerging problem

Ahmed I, et al. Int J Infect Dis. 2020.

  • This article reviews the incidence and burden of non-tuberculous mycobacteria infections and highlights why the true extent is unknown.
  • The reasons behind estimation of both incidence and burden are considered in detail and include complex diagnosis and NTM not being considered until late in the course of disease.
  • Research needs and possibilities are identified and discussed in detail and include efforts towards rapid diagnostic tests and the identification of biomarkers to monitor treatment response

Real-life evaluation of clinical outcomes in patients undergoing treatment for non-tuberculous mycobacteria lung disease: A ten-year cohort study

Aliberti S, et al. Respir Med. 2020;164.

  • This observational retrospective study investigated NTM-LD outcomes in a real-life setting in 170 adults who received treatment for NTM-LD in Milan from 2007 to 2017.
  • Mycobacterium avium complex (MAC) was the most commonly isolated species (71.2%), followed by M. kansasii (9.4%) and M. xenopi (7.1%).
  • Adverse events occurred in 37.6% of patients and cultures during treatment could not be performed in 42.9% of patients due to absence of spontaneous sputum production or patients’ willingness to undergo bronchoscopy.
  • Of the entire study population, treatment outcomes were unsuccessful in 35.3% of patients with the reasons being treatment halted (13.5%), recurrence (11.2%), re-infection (5.3%), treatment failure (4.1%) and relapse (1.2%).

Comparison of the chest computed tomography findings between patients with pulmonary tuberculosis and those with Mycobacterium avium complex lung disease

Miura K, et al. Respir Investig. 2019.

  • This retrospective study compared the differences in chest CT findings between patients meeting the diagnostic criteria of pulmonary TB or Mycobacterium avium complex (MAC) lung disease from May 2005 to August 2015 at Shimane University Hospital, Japan.
  • CT images were evaluated for abnormal findings and classified accordingly. Characteristics which were compared included presence and distribution of granular shadows, bronchiectasis and cavities.
  • Whereas extensive bronchiectasis, cavity lesions and granular shadows connected to bronchiectasis were more common amongst MAC lung disease patients, granular shadows and bronchiectasis were generally distributed to the right upper lobe and left upper division in patients with pulmonary TB showing that chest CT findings could be useful in differentiating the diseases.

Job code NP-UK-00130. Date 1 Apr 2020.